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Integratore alimentare di alfalattoalbumina

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ALAC in letteratura

Ruolo nel latte materno:

Heine WE, Klein PD, Reeds PJ. The importance of alpha-lactalbumin in infant nutrition. J Nutr. 1991 Mar;121(3):277-83.

Taylor SN, Basile LA, Ebeling M, Wagner CL. Intestinal permeability in preterm infants by feeding type: mother's milk versus formula. Breastfeed Med. 2009 Mar;4(1):11-5.

Catassi C, Bonucci A, Coppa GV, Carlucci A, Giorgi PL. Intestinal permeability changes during the first month: effect of natural versus artificial feeding. Pediatr Gastroenterol Nutr. 1995 Nov;21(4):383-6.

Azioni protettive, anti-infiammatorie e anti-batteriche intestinali:

Ushida Y, Shimokawa Y, Matsumoto H, Toida T, Hayasawa H. Effects of bovine alpha-lactalbumin on gastric defense mechanisms in naive rats. Biosci Biotechnol Biochem. 2003 Mar;67(3):577-83

Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine alpha-lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem. 2001 May;65(5):1104-11.

Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE. A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism. J Nutr. 2010 Feb;140(2):382-91.

Pellegrini A, Thomas U, Bramaz N, Hunziker P, von Fellenberg R. Isolation and identification of three bactericidal domains in the bovine alpha-lactalbumin molecule. Biochim Biophys Acta. 1999 Feb 2;1426(3):439-48.

Aumento triptofano plasmatico, quindi serotonina cerebrale:

Markus CR, Olivier B, Panhuysen GE, Van Der Gugten J, Alles MS, Tuiten A, Westenberg HG, Fekkes D, Koppeschaar HF, de Haan EE. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr. 2000 Jun;71(6):1536-44.

  • Choi S, DiSilvio B, Fernstrom MH, Fernstrom JD. Effect of chronic protein ingestion on tyrosine and tryptophan levels and catecholamine and serotonin synthesis in rat brain. Nutr Neurosci. 2011 Nov;14(6):260-7.

Funzioni cognitive:

Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002 Jun;75(6):1051-6.

  • Markus CR, Jonkman LM, Lammers JH, Deutz NE, Messer MH, Rigtering N. Evening intake of alpha-lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. Am J Clin Nutr. 2005 May;81(5):1026-33.

Schmitt JA, Jorissen BL, Dye L, Markus CR, Deutz NE, Riedel WJ. Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein. J Psychopharmacol. 2005 Jul;19(4):375-84.

Booij L, Merens W, Markus CR, Van der Does AJ. Diet rich in alpha-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls. J Psychopharmacol. 2006 Jul;20(4):526-35

Markus CR, Jonkman LM. Attention switching after dietary brain 5-HT challenge in high impulsive subjects. J Psychopharmacol. 2007 Sep;21(7):700-8

Umore e sonno:

Merens W, Booij L, Markus R, Zitman FG, Onkenhout W, Van der Does AJ. The effects of a diet enriched with alpha-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls. Br J Nutr. 2005 Sep;94(3):415-22.

Epilessia:

Favale E, Rubino V, Mainardi P, Lunardi G, Albano C. Anticonvulsant effect of fluoxetine in humans. Neurology. 1995 Oct;45(10):1926-7.

Lunardi G, Mainardi P, Rubino V, Fracassi M, Pioli F, Cultrera S, Albano C. Tryptophan and epilepsy. Adv Exp Med Biol. 1996;398:101-2.

Mainardi P, Albano C. Is the antiepileptic effect of the ketogenic diet due to ketones? Med Hypotheses. 2008;70(3):536-9. Epub 2007 Aug 21

Mainardi P, Leonardi A, Albano C.. Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy. .Med Hypotheses. 2008;70(4):876-9.

Citraro R, Scicchitano F, De Fazio S, Raggio R, Mainardi P, Perucca E, De Sarro G, Russo E. Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. Epilepsy Res. 2011 Jun;95(1-2):60-9.

Russo E, Scicchitano F, Citraro R, Aiello R, Camastra C, Mainardi P, Chimirri S, Perucca E, Donato G, De Sarro G. Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience. 2012 Dec 13;226:282-8.

Errichiello L, Pezzella M, Santulli L, Striano S, Zara F, Minetti C, Mainardi P, Striano P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011 Dec;26(14):2573-5.

Cos'è l'ALAC

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