Attività di ricerca

Le aree di ricerca

Kolfarma vanta collaborazioni con prestigiosi instituti di ricerca di carattere internazionale finalizzati alla compresione dei meccanismi fisiopatologici di condizioni neuropsichiatiche quali i disturbi del comportamento, i disturbi del sonno e l’epilessia.

Attraverso lo studio approfondito della fisiologia dei neurotrasmettitori a livello del sistema nervoso centrale, ed il ruolo del microbiota come
componente attivo nella modulazione dell’asse morfo-funzionale tra intestino e cervello, Kolfarma ricerca e sviluppa prodotti con l’obiettivo di fornire soluzioni concrete, efficaci e sicure.

Oltre ad integratori alimentari, Kolfarma sta sviluppando un Alimento a Fini Medici Speciali (AMFS) per il trattamento dell’Epilessie Farmacoresisenti

Effetto anti-infiammatorio e anti-batterico intestinale:
  • Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE. A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism. J Nutr. 2010 Feb;140(2):382-91.
  • Ushida Y, Shimokawa Y, Matsumoto H, Toida T, Hayasawa H. Effects of bovine alpha-lactalbumin on gastric defense mechanisms in naive rats. Biosci Biotechnol Biochem. 2003 Mar;67(3):577-83
  • Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine alpha- lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem. 2001 May;65(5):1104-11.
  • Pellegrini A, Thomas U, Bramaz N, Hunziker P, von Fellenberg R. Isolation and identification of three bactericidal domains in the bovine alpha-lactalbumin molecule. Biochim Biophys Acta. 1999 Feb 2;1426(3):439-48.
Effetto sull’umore e sul sonno:
  • Merens W , Booij L, Markus R, Zitman FG, Onkenhout W , Van der Does AJ. The effects of a diet enriched with alpha-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls. Br J Nutr. 2005 Sep;94(3):415-22.
Effetto sulle funzioni cognitive:
  • Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002 Jun;75(6):1051-6.
  • Markus CR, Jonkman LM, Lammers JH, Deutz NE, Messer MH, Rigtering N. Evening intake of alpha- lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. Am J Clin Nutr. 2005 May;81(5):1026-33.
  • Schmitt JA, Jorissen BL, Dye L, Markus CR, Deutz NE, Riedel WJ. Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha- lactalbumin protein. J Psychopharmacol. 2005 Jul;19(4):375-84.
  • Booij L, Merens W , Markus CR, Van der Does AJ. Diet rich in alpha-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls. J Psychopharmacol. 2006 Jul;20(4):526-35
  • Markus CR, Jonkman LM. Attention switching after dietary brain 5-HT challenge in high impulsive subjects. J Psychopharmacol. 2007 Sep;21(7):700-8
Effetti su modelli sperimentali di epilessia:
  • Lunardi G, Mainardi P, Rubino V, Fracassi M, Pioli F, Cultrera S, Albano C. Tryptophan and epilepsy. Adv Exp Med Biol. 1996;398:101-2.
  • Mainardi P, Leonardi A, Albano C.. Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy. Med Hypotheses. 2008;70(4):876-9.
  • Citraro R, Scicchitano F, De Fazio S, Raggio R, Mainardi P, Perucca E, De Sarro G, Russo E. Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. Epilepsy Res. 2011 Jun;95(1-2):60-9.
  • Russo E, Scicchitano F, Citraro R, Aiello R, Camastra C, Mainardi P, Chimirri S, Perucca E, Donato G, De Sarro G. Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience. 2012 Dec 13;226:282-8.
  • Errichiello L, Pezzella M, Santulli L, Striano S, Zara F, Minetti C, Mainardi P, Striano P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011 Dec;26(14):2573-5.
  • De Caro C, Leo A, Nesci V, Ghelardini C, di Cesare Mannelli L, Striano P, Avagliano C, Calignano A, Mainardi P, Constanti A, Citraro R, De Sarro G, Russo E. Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. Sci Rep. 2019 Sep 27;9(1):13983.